Exposure to titanium dioxide and risk of lung cancer in a population-based study from Montreal.
نویسندگان
چکیده
OBJECTIVES This study assessed the lung cancer risk from exposure to titanium dioxide, an important pigment with limited evidence of carcinogenicity in experimental animals but sparse data for humans. METHODS The risk of lung cancer among residents in Montreal, Canada, was analyzed, including 857 histologically confirmed cases of lung cancer diagnosed during 1979-1985 among men aged 35-70 years and a group of referents comprising 533 randomly selected, healthy residents and 533 persons with cancer in organs other than the lung. Exposure to titanium dioxide and other titanium compounds was assessed by a team of industrial hygienists on the basis of a detailed occupational questionnaire. RESULTS Thirty-three cases and 43 referents were classified as exposed to titanium dioxide. The odds ratio was 0.9 [95% confidence interval (95% CI) 0.5-1.5]. No trend was apparent according to the estimated frequency, level, or duration of exposure. The odds ratio was 1.0 (95% CI 0.3-2.7) for medium or high exposure for at least 5 years. Few subjects were classified as exposed to titanium dioxide fumes or to other titanium compounds, but the risk of lung cancer was nonsignificantly increased for exposure to these agents. CONCLUSIONS Although misclassification of exposure and low exposure prevalence might have resulted in false negative results, this study does not suggest that occupational exposure to titanium dioxide increases the risk of lung cancer.
منابع مشابه
Risk assessment of mortality from silicosis and lung cancer Workers in machine factories and traditional brick production workshops with crystalline silica
Introduction: Exposure to dust is an essential factor in the brick production industry. Determining the mortality rate from silicosis and lung cancer is very important in exposure to crystalline silica dust. Therefore, this study was conducted to risk assessment of workers in machine factories and traditional brick production workshops. Materials and Methods: This cross-sectional study was con...
متن کاملAssessment of lung cancer risk due to indoor radon exposure in inhabitants of the state of Azad Kashmir Pakistan
Background: Several epidemiological studies conducted on underground miner’s show that exposure to elevated levels of radioactive radon gas is expected to increase the risk of lung cancer. Relative risk of lung cancer is almost linear with radon exposure. Elevated concentrations of radon are not only reported within mines but also for closed indoor environment of general public houses....
متن کاملتعیین میزان مواجهه ی شغلی کارگران واحد ماهیچه گیری با گرد و غبار سیلیس کریستالی تنفسی
Introduction: Occupational exposure to crystalline silica increases the risk of lung cancer and restrictive lung disease with extensive fibrosis. Silica dust is a major health hazard in foundry factories. The aim of this study was to determine core making workers’ exposure to respirable crystalline silica dust in a foundry factory. Material and Method: This cross-sectional study was conducte...
متن کاملHealth Assessment Based On the Exposure of Alpha Radioactivity in Narghile Smoking
Introduction: Smokers and non-smokers are at the risk of developing lung cancer when exposed to alpha rays as a result of the relatively low levels of radium and radon that may be present in different tobacco species. There is a great interest in studies and research on the radionuclides in narghile tobacco emitting alpha particles to know the relationship between smok...
متن کاملSurvey of Nitrate Removal Method from Aqueous Solutions Using Titanium Dioxide Nano-Photocatalyst
Background & objectives: Because of its very high solubility, nitrate penetrates easily into soil and underground waters. Surface waters such as lakes, reservoirs, and rivers are exposed to nitrate pollution. Photocatalytic processes have a high potential for nitrate removal due to complete oxidation, lack of formation of multi-cycle metabolites and the availability of catalysts. The purpose of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Scandinavian journal of work, environment & health
دوره 27 4 شماره
صفحات -
تاریخ انتشار 2001